Metabolic Insights: UC San Diego Study Reveals Link Between Cell Metabolism and Depression

Scientists at the University of California (UC) San Diego School of Medicine have revealed a groundbreaking link between cell metabolism and depression, challenging traditional views of depression as solely a mental disorder. Using metabolomics, the study examined blood chemistry in 99 patients with treatment-resistant depression and suicidal thoughts. The findings identified distinct metabolic markers for depression and suicide risk, differing between men and women. This prompts a reevaluation of our understanding of depression. Led by UC San Diego School of Medicine researchers, the study's metabolomics methodology allows for a comprehensive analysis of blood biochemicals, holding potential for diagnostic and therapeutic advancements.

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[1] Pan, L.A., Naviaux, J.C., Wang, L. et al. Metabolic features of treatment-refractory major depressive disorder with suicidal ideation. Transl Psychiatry 13, 393 (2023). https://doi.org/10.1038/s41398-023-02696-9